Title: "Integrating Genomics and Proteomics: Using Mass Spectrometry to Annotate the Genome"
Abstract: Much of our knowledge about proteins has been inferred from nucleic acid sequence data, but we know that alternative splicing, proteolysis and post translational modification greatly expand the diversity of the proteome. Mass spectrometry-based proteomics is emerging as a powerful new analytical technology, but there are multiple levels of disambiguation required to link MS spectra to protein products. Issues in data integration and statistical assessment of identification significance are discussed. Examples will be drawn from cancer proteomics.
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